文章摘要
李式浩,徐培坤,李显雄,等.术后辅助不同放化疗方案对高级别胶质瘤患者的预后分析[J].安徽医药,2017,21(10):1858-1860.
术后辅助不同放化疗方案对高级别胶质瘤患者的预后分析
The prognostic of high-grade glioma patients in post-operation for different chemoradiotherapy in adjuvant treatment
投稿时间:2017-01-19  
DOI:
中文关键词: 高级别胶质瘤  生存期分析  化疗  替莫唑胺
英文关键词: 
基金项目:安徽省科技攻关计划项目(1301042208)
作者单位E-mail
李式浩 安徽医科大学第一附属医院神经外科,安徽 合肥 230022  
徐培坤 安徽医科大学第一附属医院神经外科,安徽 合肥 230022 xpkayfy@163.com 
李显雄 安徽医科大学第一附属医院神经外科,安徽 合肥 230022  
胡光东 安徽医科大学第四附属医院神经外科,安徽 合肥 230031  
杨成子 安徽医科大学第一附属医院神经外科,安徽 合肥 230022  
侯保森 安徽医科大学第一附属医院神经外科,安徽 合肥 230022  
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中文摘要:
      目的 分析术后辅助放化疗对高级别胶质瘤(HGG)患者生存期的影响。方法 选择手术切除且经病理证实为HGG的患者81例,其中术后辅助替莫唑胺(TMZ)同步放化疗及6个疗程标准化疗(Stupp方案)患者42例,Stupp方案后TMZ继续化疗39例。分析术后不同放化疗方案对患者生存期的临床疗效。结果 Stupp方案后继续化疗组平均生存期31.87个月较Stupp方案化疗组平均生存期24.38个月长(P=0.002),差异有统计学意义。TMZ化疗的不良反应主要发生在前6周期,延长化疗周期并未增加化疗毒性。结论 Stupp方案化疗结束后继续化疗可以延长HGG患者的总生存期(OS)。
英文摘要:
      Objective To analyzed the influence of different adjuvant chemoradiotherapy treatment strategies for high-grade glioma (HGG) patients after operation.Methods Selected eighty-one HGG patients proved by pathology.Forty-two cases received post-operative radiotherapy accompanied with chemotherapy and the later of 6 cycles groups chemotherapy (Stupp protocol).Thirty-nine cases was more than 6 cycles groups,to evaluated the curative effect of the two groups survival time.Results The chemotherapy protocol of more than 6 cycles groups average overall survival(OS) was 31.87 months more than 6 cycles groups 24.38 mouths (P=0.002).It had significant difference between the two group.TMZ toxicity was mainly occurred in 6 cycles.No obvious adverse reaction was observed in long-term chemotherapy.Conclusions Continued chemotherapy when the 6 cycles groups finished can increasing the average survival time of HGG patients.
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