文章摘要
蒙雪芳,杜顺霞,梁秋云,等.红肉火龙果果原汁对肾性高血压大鼠的降压作用研究[J].安徽医药,2018,22(1):33-37.
红肉火龙果果原汁对肾性高血压大鼠的降压作用研究
Study on the antihypertensive effect of red pitaya juice in renal hypertensive rats
投稿时间:2017-04-13  
DOI:
中文关键词: 红肉火龙果  果原汁  肾性高血压  肾素-血管紧张素-醛固酮系统
英文关键词: 
基金项目:广西省自然科学基金项目(2015GXNSFAA139196)
作者单位E-mail
蒙雪芳 广西医科大学药学院,广西 南宁 530021  
杜顺霞 广西医科大学药学院,广西 南宁 530021  
梁秋云 广西医科大学药学院,广西 南宁 530021 670518680@qq.com 
谭珍媛 广西医科大学药学院,广西 南宁 530021  
周园贵 广西医科大学附属肿瘤医院,广西 南宁 530021  
摘要点击次数: 2319
全文下载次数: 690
中文摘要:
      目的 研究红肉火龙果果原汁(RPJ)对肾性高血压大鼠(RHR)的降压作用。方法 采用两肾一夹(2K1C)针灸针缩窄法制备大鼠肾性高血压模型,将造模成功的大鼠随机分为假手术组、模型组、卡托普利组和RPJ高、中、低剂量组,连续灌胃8周末,测定各组大鼠收缩压(SBP),记录左肾重量与右肾重量比值(LK/RK)和左心室重量指数(LVMI);光学显微镜观察心肌组织及主动脉弓病理学变化;ELISA法测定大鼠血浆、心肌及肾脏血管紧张素Ⅱ(AngⅡ)、醛固酮(Ald)及内皮素-1(ET-1)含量。结果 与模型组相比,RPJ高、中剂量组大鼠血压均明显降低(P<0.05),LK/RK比值明显升高(P<0.05),其中高剂量组能够明显降低LVMI值(P<0.05);RPJ高、中剂量组可以使血浆、心肌及肾脏中的AngⅡ、Ald和ET-1含量不同程度减少(P<0.01或P<0.05),RPJ低剂量组血浆AngⅡ含量明显下降(P<0.05)。结论 RPJ对肾性高血压有较好的治疗作用,值得进一步深入研究。
英文摘要:
      Objective To explore the antihypertensive effects of red pitaya juice (RPJ) in renal hypertensive rats (RHR). Methods The model of renal hypertension rats was established by two-kidney one-clip (2K1C) acupuncture needle narrowed method.After operation,the rats were randomly assigned into 6 groups:sham-operated group,model group,captopril group,high-dose,middle-dose,low-dose groups of RPJ.Then drug was given continuously by ig for 8 weeks.After 8-week treatment,the systemic blood pressure (SBP) was measured;The ratio of left kidney/right kidney (LK/RK) and the left ventricular mass index (LVMI) were recorded;pathological changes of myocardial tissue and aortic arch were observed by optical microscope;and angiotensin Ⅱ (AngⅡ),aldosterone (Ald) and endothelin-1 (ET-1) in plasma,heart and kidney tissue were measured by ELISA. Results Compared with model group,the SBP of RHR in RPJ high-dose,middle-dose groups were significantly reduced (P<0.05),while the levels of LK/RK were increased (P<0.05);the LVMI in RPJ high-dose were significantly lower (P<0.05);AngⅡ,Ald and ET-1 level in plasma,heart and kidney tissue of RPJ high-dose and middle-dose groups were reduced to varying degrees (P<0.01 or P<0.05);AngⅡ in plasma of RPJ low-dose was significantly reduced (P<0.05). Conclusions RPJ has a better effect on the treatment of renal hypertension,which is worth further research.
查看全文   查看/发表评论  下载PDF阅读器
关闭

分享按钮