文章摘要
黄萃园,张洪,白瑞丹.Toll样受体4(896A/G)基因多态性与溃疡性结肠炎易感性的Meta分析[J].安徽医药,2018,22(1):63-67.
Toll样受体4(896A/G)基因多态性与溃疡性结肠炎易感性的Meta分析
Association between the polymorphism (896A/G) of TLR4 gene and susceptibility of ulcerative colitis:a Meta-analysis
投稿时间:2016-10-19  
DOI:
中文关键词: Toll样受体4  基因多态性  冠心病  Meta分析
英文关键词: 
基金项目:
作者单位E-mail
黄萃园 武汉大学人民医院药学部,湖北 武汉 430060  
张洪 武汉大学人民医院药学部,湖北 武汉 430060 cuiandli92@163.com 
白瑞丹 武汉大学人民医院药学部,湖北 武汉 430060  
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中文摘要:
      目的 研究Toll样受体4(TLR4)896A>G位点基因多态性与溃疡性结肠炎(UC)发病风险的关系。方法 检索相关英文及中文数据库筛选文献,以OR值及95%CI为效应指标,运用RevMan 5.2和Stata 11.0进行Meta分析和敏感性分析,并采用Egger′s test评价发表偏倚。结果 研究共纳入14篇文献,包括2 174例UC患者和3 134例对照者。Meta分析结果表明携带等位基因G的人群较携带等位基因A的人群患UC的风险性增加,在各个基因模型下均差异有统计学意义[等位基因模型G/A:OR=1.41,95%CI(1.21~1.66),P<0.000 1;显性模型AG+GG/AA:OR=1.37,95%CI(1.16~1.62),P=0.000 2;隐性模型GG/AA+AG:OR=3.74,95%CI(1.78~7.86),P=0.000 5;共显性模型AG/AA:OR=1.42,95%CI(1.07~1.87),P=0.01;共显性模型GG/AA:OR=3.85,95%CI(1.82~8.12),P=0.000 4]。亚组分析结果表明,在等位基因模型G/A、显性模型AG+GG/AA、共显性模型AG/AA下,差异仅在白种人中存在。结论 TLR4 896A>G基因多态性与UC易感性相关,携带等位基因G会增加白种人患UC的发病风险。由于该研究纳入有关亚洲人群及非洲人群的文献数量较少,相关结果需要更多研究予以验证。
英文摘要:
      Objective To study the relationship between toll like receptor 4(TLR4) 896A>G polymorphism and the risk of ulcerative colitis (UC). Methods The English and Chinese database were searched to screen the relevant literatures.RevMan 5.2 and Stata 11.0 software were used for the meta-analysis and sensitivity analysis,the odds ratio (OR value) and 95% confidence interval (95%CI) were calculated.Egger′s test was used for publication bias. Results A total of 14 articles were included in the study with 2174 UC patients and 3134 controls.Meta-analysis showed that compared with allele A,the allele Gincreased the risks of ulcerative colitis significantly[allele model G/A:OR=1.41,5%CI(1.21-1.66,P<0.000 1);dominant model AG+GG/AA:OR=1.37,5%CI(1.16-1.62,P=0.000 2);recessive model GG/AA+AG:OR=3.74,5%CI(1.78-7.86),P=0.000 5;co-dominant model AG/AA:OR=1.42,5%CI (1.07-1.87),P=0.01;co-dominant model GG/AA:OR=3.85,5%CI (1.82-8.12),P=0.000 4].But,the results of subgroup analysis showed that the differences only existed among caucasians in allele model G/A,dominant model AG+GG/AA and co-dominant model AG/AA. Conclusions TLR4 896A>G polymorphism is associated with the susceptibility of ulcerative colitis,and the allele Gincreases the risks of ulcerative colitis significantly in caucasians.Due to the limited quantity of the included studies about Asian and African population,further studies are needed to validate our findings.
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