文章摘要
王晶晶,杨琍琦.33~36周早产儿唾液皮质醇在高胆红素血症中的临床意义[J].安徽医药,2018,22(2):254-256.
33~36周早产儿唾液皮质醇在高胆红素血症中的临床意义
The clinical significance of salivary cortisol to the hyperbilirubinemia of premature infants in 33 to 36 weeks
投稿时间:2016-11-22  
DOI:
中文关键词: 早产儿  唾液皮质醇  高胆红素血症
英文关键词: 
基金项目:安徽省科技攻关项目(1604a0802080);安徽医科大学科研基金(2015xkj104)
作者单位E-mail
王晶晶 安徽医科大学第二附属医院儿科,安徽 合肥 230061  
杨琍琦 安徽医科大学第二附属医院儿科,安徽 合肥 230061 2455974830@qq.com 
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中文摘要:
      目的 研究33~36周早产儿生后7 d唾液皮质醇水平变化及其在早产儿高胆红素血症中的临床意义。 方法 选择收住安徽医科大学第二附属医院新生儿科33~36周早产儿41例,分为33~<34周、34~<35周、35~<36周、36~<37周四组,检测生后第1、3、7天唾液皮质醇水平以及病程中血清总胆红素峰值,并进行相关性分析。 结果 (1)四组早产儿生后7 d内唾液皮质醇水平比较,第1天低于第3天和第7天(P<0.001),第3天低于第7天(P<0.001)。(2)33~36周早产儿生后第7天唾液皮质醇水平与血清总胆红素水平有低度负相关性(r=-0.340,P<0.05)。(3)33~36周早产儿生后7 d内唾液皮质醇的变化水平与血清胆红素水平的变化水平有低度负相关性(r=-0.366,P<0.05)。 结论 33~36周早产儿生后7 d内唾液皮质醇水平逐渐升高。早产儿的快速应答能力较弱,在一定范围内,血清胆红素水平变化越大,对肾上腺皮质抑制作用越强,表现为皮质醇变化水平的降低。
英文摘要:
      Objective To investigate the changes of salivary cortisol (SC) levels within 7 days after born,and the clinical significance of SC on predication and therapeutical evaluation in the hyperbilirubinemia of premature infants in 33-36 weeks gestational age. Method41 premature infants of gestational age from 33-36 weeks in the NICU from the Second Affiliated Hospital of Anhui Medical University were enrolled.They were divided into 4 group,which were 33-<34 weeks group,34-<35 weeks group,35-<36 weeks group,36-<37 weeks group.All group included the data of the highest level of total serum bilirubin (TSB) and SC levels on 1,3,7d after birth,and the corresponding comparison was conducted. Results (1)In the same group,the levels of SC on 1d was significantly lower than that on 3,7 d,and the levels on 3d was lower than that on 7 d (P<0.001).(2)The SC levels on 7 d was correlated with the levels of TSB on 7 d (r=-0.340,P<0.05).(3)The change of SC levels correlated with the levels of TSB (r=-0.366,P<0.05). ConclusionThe level of SC is increased in 7 d after born.Premature infants′ response ability is lower than normal.Within limits,the higher levels of TSB,the stronger inhibition to adrenal cortex,which is performed by the change of SC′s level.
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