文章摘要
侯卫东,禹远远,李会敏,等.甲状腺乳头状癌中紧密连接蛋白 -1的表达与临床意义[J].安徽医药,2022,26(1):136-139.
甲状腺乳头状癌中紧密连接蛋白 -1的表达与临床意义
Expressions and clinical significance of claudin-1 in papillary thyroid carcinoma
  
DOI:10.3969/j.issn.1009-6469.2022.01.031
中文关键词: 甲状腺肿瘤  癌,乳头状  甲状腺良性病变  诊断,鉴别  紧密连接蛋白 -1
英文关键词: Thyroid neoplasms  Carcinoma, papillary  Benign thyroid lesions  Diagnosis, differential  Claudin-1 antigen
基金项目:
作者单位
侯卫东 平顶山市第一人民医院内分泌代谢科河南平顶山467099 
禹远远 平顶山市第一人民医院内分泌代谢科河南平顶山467099 
李会敏 平顶山市第一人民医院内分泌代谢科河南平顶山467099 
刘艳晓 平顶山市第一人民医院内分泌代谢科河南平顶山467099 
刘艳锋 中国人民解放军联勤保障部队第九八九医院平顶山医疗区病理科河南平顶山 467099 
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中文摘要:
      目的探讨甲状腺乳头状癌( PTC)组织中紧密连接蛋白 -1(Claudin-1)的表达与临床意义。方法收集 2017年 1月至 2019年 10月平顶山市第一人民医院和中国人民解放军联勤保障部队第九八九医院平顶山医疗区甲状腺手术存档标本共计 271例。采用免疫组化 EliVision两步法检测 116例 PTC、145例甲状腺良性病变( BTL)和 10例甲状腺滤泡癌中 Claudin-1的表达状况,并分析其表达与 PTC病人临床病理特征之间的关系。结果在 116例 PTC中 Claudin-1高表达率为 97.4%;在 145例 BTL中高表达率为 11.7%;在 10例滤泡癌中高表达率为 10.0%。此外, Claudin-1在 16例有 PTC转移的淋巴结中全部高表达
英文摘要:
      Objective To investigate the expression and clinical significance of claudin-1 in papillary thyroid carcinoma (PTC). Methods From January 2017 to October 2019, 271 archived thyroid surgery specimens in Pingdingshan First People's Hospital andPingdingshan Medical District of the 989 Hospital of the joint logistics support force of the Chinese PLA were collected. The expres-sions of claudin-1 in 116 cases of PTC, 145 cases of benign thyroid lesions (BTL) and 10 cases of follicular thyroid carcinoma were de-tected by immunohistochemical MaxVision method, and the relationship between them and the clinical pathological characteristics wasanalyzed.Results The high expression rate of claudin-1 in 116 cases of PTC was 97.4%. The high expression rate of claudin-1 in 116 cases of BTL was 11.7%. The high expression rate of claudin-1 in 10 cases of follicular thyroid carcinoma was 10.0%. In addition, clau-din-1 was highly expressed in all 16 lymph nodes with PTC metastasis, which was consistent with the expression of PTC in thyroid. Noexpression of claudin-1 was found in the normal thyroid tissues around 40 cases of tumors. The expression of claudin-1 in PTC and BTL was significantly different(χ2= 189.282,P < 0.001), the expression of claudin-1 in PTC and follicular carcinoma was still statistically sig-nificant(χ2 = 71.810,P < 0.001). The expression of claudin-1 was not related with age, gender, number and diameter of tumor nodules, lymph node metastasis, and TNM staging (P > 0.05). The sensitivity of claudin-1 in the diagnosis of PTC was 97.4%. The specificity of claudin-1 was 88.3% in the differential diagnosis of PTC and BTL, and 90.0% in the differential diagnosis of PTC follicular carcinoma.Conclusion Claudin-1 is helpful for the differential diagnosis of PTC and BTL, as well as PTC and follicular carcinoma. The overex-pression of claudin-1 may be the key factor of strong adhesion of PTC tumor cells.
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