文章摘要
彭影,彭程,姚伶俐,等.外阴颗粒细胞瘤 3例及文献回顾[J].安徽医药,2022,26(1):143-146.
外阴颗粒细胞瘤 3例及文献回顾
Granular cell tumor of vulva: 3 case reports and literature review
  
DOI:10.3969/j.issn.1009-6469.2022.01.033
中文关键词: 颗粒细胞瘤  外阴肿瘤  包块切除  女性
英文关键词: Granular cell tumor  Tumor of vulva  Mass removal  Femininity
基金项目:
作者单位E-mail
彭影 中国科学技术大学附属第一医院安徽省立医院妇产科安徽合肥 230001  
彭程 中国科学技术大学附属第一医院安徽省立医院妇产科安徽合肥 230001  
姚伶俐 中国科学技术大学附属第一医院 病理科安徽合肥 230001  
蒋来 中国科学技术大学附属第一医院安徽省立医院妇产科安徽合肥 230001  
胡卫平 中国科学技术大学附属第一医院安徽省立医院妇产科安徽合肥 230001 syhwp@163.com 
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中文摘要:
      目的探讨女性外阴颗粒细胞瘤( granular cell tumor,GCT)临床特征、诊断、治疗及预后。方法回顾性分析 2018年 1月至 2019年 11月中国科学技术大学附属第一医院(安徽省立医院)妇科收治的 3例女性外阴 GCT病人的临床资料。结果 3例病人年龄分别为 31岁、 49岁、 39岁,外阴包块均无症状,其中病例 1为妊娠期发现外阴包块,产后无明显缩小就诊,另 2例为无意中发现外阴包块且随访期间进行性增大就诊。病例 1术前未行活检,因包块与周围正常组织无明显边界,同时切除包块外正常组织 0.5~1.0 cm;病例 2先于门诊行单纯外阴包块切除术,术后病理提示切缘阳性入院再次扩大手术范围,达原切缘外 1~2 cm;病例 3术前外阴活检提示 GCT,行外阴包块局部扩大切除术,达病灶外 1~2 cm。3例病人均顺利出院,术后分别随访 20个月、 14个月、 2个月未复发。结论女性外阴 GCT发病率低,多无临床症状,易被忽视。虽多为良性病变,但有少数有复发或恶变可能,一旦发现外阴部包块应重视,必要时外阴活检确诊,一旦诊断,及时手术治疗,并定期随访。
英文摘要:
      Objective To investigate the clinical characteristics, diagnosis, treatment and prognosis of the female vulvar granulosa cell tumor (GCT).Methods The clinical data of three female patients with granulosa cell tumor of vulva who were admitted to the De-partment of Gynecology, the First Affiliated Hospital of China University of science and Technology (Anhui Provincial Hospital) fromJanuary 2018 to November 2019 were analyzed retrospectively.Results The age of the three patients were 31 years old, 49 years oldand 39 years old, the vulvar masses were all asymptomatic. Case one's vulvar mass was found during pregnancy, and there was no obvi-ous reduction after childbirth. The other two patients's vulvar mass were found inadvertently and increased during follow-up. Case 1was not biopsied before surgery, because there was no obvious boundary between the mass and surrounding normal tissue, and 0.5~1.0cm of normal tissue outside the mass was removed at the same time. Case 2 underwent with an outpatient operation, and the operationscope was expanded again due to positive pathological margin after operation,1~2 cm outside the original cutting edge. Case 3 under-went local extended resection of vulvar mass according to the vulva biopsy before the operation, reaching 1~2 cm outside the lesion. Allpatients were discharged successfully. The patients were followed up for 20 months, 14 months and 2 months without recurrence respec-tively.Conclusions The incidence of granulosa cell tumor of vulva is low, most of them have no clinical symptoms and easy to be ig-nored. Although most of them are benign lesions, a few of them are likely to recur or become malignant. Once the mass of vulva isfound, we should pay more attention to it. If necessary, the vulva biopsy should be confirmed. Once the diagnosis is made, timely surgi-cal treatment should be carried out and regular follow-up should be carried out.
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