文章摘要
郇金亮,高庆佳,唐小龙,等.组织桥接整合因子 1、Ⅰ型胶原蛋白基因、核转运蛋白基因 2与三阴性乳腺癌术后复发关系[J].安徽医药,2024,28(7):1343-1347.
组织桥接整合因子 1、Ⅰ型胶原蛋白基因、核转运蛋白基因 2与三阴性乳腺癌术后复发关系
Relationship between the expression of tissue bridging integration factor 1,type I collagen gene, nuclear transfer protein gene 2 and postoperative recurrence of triple negative breast cancer
  
DOI:10.3969/j.issn.1009-6469.2024.07.015
中文关键词: 三阴性乳腺癌  组织桥接整合因子 1  Ⅰ型胶原蛋白基因  核转运蛋白基因 2(KPNA2)  复发  预测价值
英文关键词: Triple negative breast neoplasms  Bridging integrator-1 (BIN1)  Collagen type Ⅰ (COL1A1)  Karyopherin α2 (KPNA2)  Recurrence  Predictive value
基金项目:上海市卫生系统优秀青年医学人才培养项目( PWRq2018-911)
作者单位
郇金亮 上海市第八人民医院普外科上海200235 
高庆佳 青州市人民医院神经外科山东青州 262599 
唐小龙 上海市第八人民医院普外科上海200235 
易宜 上海市第八人民医院普外科上海200235 
吴凯铠 上海市第八人民医院普外科上海200235 
黄雄 上海市第八人民医院普外科上海200235 
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中文摘要:
      目的探究组织桥接整合因子 1(BIN1)、Ⅰ型胶原蛋白基因(COL1A1)、核转运蛋白基因 2(KPNA2)表达与三阴性乳腺癌(TNBC)术后复发关系及联合检测意义。方法选取 2019年 5月至 2020年 5月上海市第八人民医院行手术治疗的 TNBC病人 80例,根据术后 2年是否复发分为复发组、未复发组,比较两组临床资料、组织 BIN1、COL1A1、KPNA2基因表达,复发的相关影响因素采用单因素与多因素 logistic回归分析,组织 BIN1、COL1A1、KPNA2基因表达预测术后复发的价值采用受试者操作特征曲线(ROC曲线)分析,组织 BIN1、COL1A1、KPNA2基因表达与复发时间关系采用 Pearson分析,比较不同组织 BIN1、COL1A1、KPNA2基因表达病人无复发生存期( RFS)。结果复发组 T分期、 N分期与未复发组比较,差异有统计学意义( P<0.05);复发组组织 BIN1 mRNA表达为 0.24±0.07,低于未复发组的 0.35±0.10(P<0.05),复发组组织 COL1A1 mRNA、KPNA2 mRNA表达分别为 2.07±0.62、2.91±0.84,高于未复发组的 1.48±0.43、1.85±0.60(P<0.05); T分期、 N分期、 COL1A1 mRNA、KPNA2 mRNA均是复发相关独立危险因素, BIN1 mRNA是复发相关独立保护因素( P<0.05); BIN1 mRNA、COL1A1 mRNA、KPNA2 mRNA的 AUC分别为 0.76、0.80、0.78,三者联合的 AUC为 0.94;BIN1 mRNA与复发时间呈负相关(r=-0.79,P<0.001),COL1A1 mRNA、KPNA2 mRNA与复发时间呈正相关(r=0.77、0.78,均 P<0.001); BIN1 mRNA高水平病人 RFS长于低水平病人, COL1A1 mRNA、KPNA2 mRNA高水平病人 RFS短于低水平病人(P<0.05)。结论 BIN1 mRNA、COL1A1 mRNA、KPNA2 mRNA与 TNBC术后复发风险、复发时间有关,联合检测可作为早期预测术后复发的一个可靠方案,为临床治疗提供重要的参考信息。
英文摘要:
      Objective To explore the relationship between the expression of tissue bridging integration factor 1 (BIN1), collagen typeI gene (COL1A1), nuclear transport protein gene 2 (KPNA2) and postoperative recurrence of triple negative breast cancer (TNBC) andthe significance of combined detection.Methods Eighty patients with TNBC who underwent surgical treatment in the Eighth People'sHospital from May 2019 to May 2020 were selected and categorized into recurrence group and non-recurrence group according to whether they recurred 2 years after surgery. The clinical data, tissue BIN1, COL1A1, and KPNA2 gene expressions were compared between the two groups, the related influencing factors of recurrence were analyzed by univariate and multivariate Logistic regression analysis, the value of tissue BIN1, COL1A1, KPNA2 gene expression in predicting postoperative recurrence was analyzed by receiver operating characteristic (ROC) curve. Pearson analysis was used to analyze the relationship between the tissue BIN1, COL1A1, KPNA2gene expression and the recurrence time. The relapse-free survival (RFS) in patients with different tissue BIN1, COL1A1 and KPNA2 gene expression was compared.Results There were significant differences in T and N Staging between the recurrence group and the non-recurrence group (P<0.05); the expression of BIN1 mRNA in the recurrent group was 0.24±0.07, which was lower than that in the non-recurrent group 0.35±0.10 (P<0.05); the expressions of COL1A1 mRNA and KPNA2 mRNA in the recurrent group were 2.07±0.62and 2.91±0.84, respectively, which were higher than those in the non-recurrent group 1.48±0.43 and 1.85±0.60 (P<0.05); T staging, Nstaging, COL1A1 mRNA and KPNA2 mRNA were independent risk factors for recurrence, and BIN1 mRNA was an independent protective factor for recurrence (P<0.05). The AUCs of BIN1 mRNA, COL1A1 mRNA, and KPNA2 mRNA were 0.76, 0.80, and 0.78, respectively, and the combined AUC of the three was 0.94; BIN1 mRNA was negatively correlated with recurrence time (r= -0.79, P< 0.001). There was a positive correlation with the recurrence time (r=0.77, 0.78, both P<0.001). The RFS was longer in patients withhigh levels of BIN1 mRNA than that in patients with low levels, and shorter in patients with high levels of COL1A1 mRNA and KPNA2mRNA than that in patients with low levels (P<0.05).Conclusions BIN1 mRNA, COL1A1 mRNA and KPNA2 mRNA are related topostoperative recurrence risk and recurrence time of TNBC. Combined detection can be used as a reliable scheme for early predictionof postoperative recurrence and provides important reference information for clinical treatment.
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