文章摘要
高华祝,侯仕强,邵尉,等.神经元特异性烯醇化酶和脑钠肽在中老年基底节区出血 85例预后中的应用研究[J].安徽医药,2024,28(7):1417-1420.
神经元特异性烯醇化酶和脑钠肽在中老年基底节区出血 85例预后中的应用研究
Application of neuron-specific enolase and brain natriuretic peptide in prognosis of 85 middle-aged and elderly patients with basal ganglia area hemorrhage
  
DOI:10.3969/j.issn.1009-6469.2024.07.032
中文关键词: 脑血管基底神经节出血  神经元特异性烯醇化酶  脑钠肽  中老年  预后
英文关键词: Basal ganglia hemorrhage  Neuron-specific enolase(NSE)  Brain natriuretic peptide(BNP)  Middle-aged and older  Prognosis
基金项目:安徽省高校自然科学研究重点项目( 2022AH050769)
作者单位E-mail
高华祝 安徽医科大学附属滁州医院、滁州市第一人民医院神经外科安徽滁州 239000  
侯仕强 安徽医科大学附属滁州医院、滁州市第一人民医院神经外科安徽滁州 239000  
邵尉 安徽医科大学附属滁州医院、滁州市第一人民医院神经外科安徽滁州 239000  
周冬瑞 安徽医科大学附属滁州医院、滁州市第一人民医院神经外科安徽滁州 239000  
姚国权 安徽医科大学附属滁州医院、滁州市第一人民医院神经外科安徽滁州 239000  
石碑田 安徽医科大学附属滁州医院、滁州市第一人民医院神经外科安徽滁州 239000 shibeitian1351@163.com 
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中文摘要:
      目的探讨神经元特异性烯醇化酶( NSE)和脑钠肽在中老年基底节区出血病人预后评估中的应用价值。方法选择 2020年 1月至 2022年 12月在安徽医科大学附属滁州医院治疗的 85例中老年基底节区出血病人进行回顾性分析,根据病人发病后 3个月的改良 Rankin量表( mRS)评分,将病人分为预后良好组和预后不良组,利用受试者操作特征曲线( ROC曲线)和 logistic回归分析评估 NSE和脑钠肽的预后价值。结果预后良好组中 NSE(13.67±4.51)μg/L明显低于预后不良组(18.36±6.52)μg/L(P<0.001)预后良好组中脑钠肽 143.00(98.00,233.80)ng/L明显低于预后不良组 230.00(120.00,400.00)ng/L(P=0.002)。 ROC曲线显示,NSE和脑钠肽的最佳截取值分别为 15.5 μg/L和 156.5 ng/L。NSE联合脑钠肽时 AUC为 0.76,与二者单独应用时的 0.73、0.70差异无统计学意义。 logistic回归分析显示出血量( P=0.017)、 NSE(P=0.003)和脑钠肽( P=0.033)是影响病人预后的独立危险因素。结论 NSE和脑钠肽在中老年基底节区出血病人的短期预后评估中具有重要价值,值得进一步研究。
英文摘要:
      Objective To explore the application value of neuron-specific enolase (NSE) and brain natriuretic peptide in prognostic evaluation of middle-aged and elderly patients with basal ganglia area hemorrhage.Methods The clinical data of 85 middle-aged andolder patients with basal ganglia area hemorrhage treated in The Affiliated Chuzhou Hospital of Anhui Medical University from January 2020 to December 2022 were retrospectively analyzed. According to the modified Rankin Scale (mRS) scoring three months afteronset, the patients were assigned into good prognosis group and poor prognosis group. Receiver operating characteristic (ROC) curveand logistic regression analysis were used to evaluate the prognostic value of NSE and brain natriuretic peptide.Results The NSE concentration in the good prognosis group was significantly lower than that in the poor prognosis group [(13.67±4.51) μg/L vs. (18.36± 6.52) μg/L, P<0.001]. The level of brain natriuretic peptide in the good prognosis group was significantly lower than that in the poor prognosis group [143.00 (98.00, 233.80) ng/L vs. 230.00(120.00,400.00)ng/L, P = 0.002]. ROC curve showed that the optimal cutoffvalues of NSE and brain natriuretic peptide were 15.5 μg/L and 156.5 ng/L respectively. The AUC of NSE combined with brain natriuretic peptide was 0.76, which was higher than that for individual use (0.73, 0.70, respectively), but the difference was not statisticallysignificant. Logistic regression analysis results showed that blood loss (P = 0.017), NSE (P = 0.003) and brain natriuretic peptide (P = 0.033) were independent risk factors affecting the prognosis of patients.Conclusion NSE and brain natriuretic peptide have important value in the short-term prognostic evaluation of middle-aged and elderly patients with basal ganglia area hemorrhage, which deserves further study.
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