| 蒋逸云,许宏亮,刘婷珽,等.12例卵巢颗粒细胞瘤的临床病理分析[J].安徽医药,待发表. |
| 12例卵巢颗粒细胞瘤的临床病理分析 |
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| 投稿时间：2026-04-25 录用日期：2026-06-08 |
| DOI： |
| 中文关键词: 卵巢颗粒细胞瘤 病理特征 鉴别诊断 预后 |
| 英文关键词: |
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| 中文摘要: |
| 摘要 目的 探讨卵巢颗粒细胞瘤（Granulosa Cell Tumor，GCT）的临床病理特征、免疫表型、鉴别诊断及预后。方法 回顾性分析2014年至2025年合肥市妇幼保健院诊断的12例卵巢GCT患者的临床资料和病理特征。所有病例均按照2020版WHO女性生殖器官肿瘤分类标准诊断，结合组织学形态和免疫组化结果进行病理诊断与分型。同时，收集患者的随访信息以评估预后。结果 本组12例GCT患者平均年龄为42.5岁（13-66岁），其中10例为成年型颗粒细胞瘤（Adult Granulosa Cell Tumor, AGCT），2例为幼年型颗粒细胞瘤（Juvenile Granulosa Cell Tumor, JGCT）。组织学上，AGCT常表现为弥漫型、微滤泡型(可见Call-Exner小体)、大滤泡型、梁索状等，较罕见的包括上皮样结构及肉瘤样形态。JGCT肿瘤细胞呈巢样分布，滤泡样结构和实性区域混合，无Call-Exner小体，核分裂象较多。GCT普遍表达α-inhibin、CD99、Calretinin、FOXL2、SF-1；Ki-67增殖指数8%-60%不等。本组9例获得随访资料，随访3-128个月，均无病生存。结论 卵巢GCT是罕见的卵巢恶性肿瘤，缺乏典型的临床症状，易远期复发，手术是主要治疗方式。因此结合影像学资料、病理学特征及免疫表型进行明确诊断，对临床制定正确的治疗方案具有重要意义。 |
| 英文摘要: |
| Abstract Objective The aim is to explore the clinical and pathological char-acteristics, immunophenotypes, differential diagnosis, and prognosis of ovarian granulosa cell tumors (GCTs). Methods The study retrospectively examined t-he medical and pathological records of 12 patients diagnosed with ovarian GC-Ts at Hefei Maternal and Child Health Hospital, spanning 2014 to 2025. All cases were reviewed and classified according to the 2020 WHO Classification of Tumors of Female Genital Organs. Histopathological analysis involved Hem-atoxylin-Eosin (HE) staining and immunohistochemistry (IHC). Patient follow-up information was collected to assess prognosis. Results Among the 12 patien-ts undergoing GCT, the average age was 42.5 years (spanning 13-66 years), in-cluding 10 cases of adult granulosa cell tumors (AGCTs) and 2 of juvenile gr-anulosa cell tumors (JGCTs). Histologically, AGCTs typically exhibited diffuse, trabecular, or microfollicular patterns (often containing Call-Exner bodies), with rare epithelioid structures and sarcomatoid morphology. In contrast, JGCTs typi-cally exhibited nests or follicular structures, frequent mitotic figures, and rare or absent Call-Exner bodies. Immunophenotypically, GCT typically express α-in-hibin、CD99、Calretinin、FOXL2、SF-1, and Ki-67 index (8%-60%). Follow-up results indicated that the prognosis of 9 patients was generally favorable. The patients were followed up for 3 to 128 months. Conclusions Ovarian GCT is a rare ovarian malignancy that lacks typical clinical symptoms and is prone to distal recurrence. Surgery is the primary treatment modality. Therefore, the combination of imaging findings, pathologic features and immunophenotypes for a clear diagnosis is of great significance for the development of rational clini-cal treatment options. |
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