| 李汝焘,武敏.核因子 E2相关因子 2调控的铁死亡通路在急性肺损伤治疗中的研究进展[J].安徽医药,2026,30(6):1061-1066. |
| 核因子 E2相关因子 2调控的铁死亡通路在急性肺损伤治疗中的研究进展 |
| Research progress on Nrf2-regulated ferroptosis pathway in the treatment of acute lung injury |
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| DOI：10.3969/j.issn.1009-6469.2026.06.001 |
| 中文关键词: 急性肺损伤 铁死亡 核因子 E2相关因子 2 脂质过氧化 谷胱甘肽过氧化物酶 4 |
| 英文关键词: Acute lung injury Ferroptosis Nuclear factor E2-related factor 2 Lipid peroxidation Glutathione peroxidase |
| 基金项目:内蒙古自治区自然科学基金项目( 2023LHMS08059) |
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| 中文摘要: |
| 急性肺损伤与急性呼吸窘迫综合征作为危重症病人高病死率的临床综合征，其病理机制与铁死亡密切相关。该研究系统阐述了铁死亡在急性肺损伤中的多维度调控机制:铁超载通过芬顿反应催化脂质过氧化级联，脂代谢异常导致多不饱和脂肪酸磷脂异常蓄积，抗氧化系统失衡。核因子 E2相关因子 2(Nrf2)作为核心调控枢纽，通过激活铁稳态通路、上调抗氧化轴、抑制脂质过氧化等多靶点网络，形成跨铁代谢、氧化应激与炎症调控的三维防御体系。研究表明，天然化合物、合成药物及中药活性成分通过特异性激活 Nrf2通路显著改善急性肺损伤模型铁死亡标志物；新型智能递送系统通过增强肺部靶向性和生物利用度，为 Nrf2激活剂的临床转化提供新策略；未来研究需聚焦 Nrf2与其他程序性死亡通路的交互网络，开发微环境响应型纳米药物及跨尺度评估体系，推动急性肺损伤治疗从分子机制向精准医学的跨越。 |
| 英文摘要: |
| Acute lung injury and acute respiratory distress syndrome, as clinical syndromes with high mortality in critically ill pa.tients, are closely associated with the pathological mechanism of ferroptosis. This review systematically elaborates the multi-dimension. al regulatory mechanisms of ferroptosis in acute lung injury: iron overload catalyzes lipid peroxidation cascades through Fenton reac.tions, abnormal lipid metabolism leads to abnormal accumulation of polyunsaturated fatty acid phospholipids, and imbalance of the anti.oxidant system occurs the antioxidant system becomes imbalanced. Nuclear factor erythroid 2-related factor 2 (Nrf2), as a core regulato. ry hub, forms a three-dimensional defense system spanning iron metabolism, oxidative stress, and regulation of inflammation through a multi-target network, including activating iron homeostasis pathways, upregulating antioxidant axes, and inhibiting lipid peroxidation.Studies have shown that natural compounds, synthetic drugs, and active components of traditional Chinese medicine significantly ame.liorate ferroptosis markers in acute lung injury models by specifically activating the Nrf2 pathway. Novel intelligent delivery systemsprovide new strategies for the clinical translation of Nrf2 activators by enhancing pulmonary targeting and bioavailability. Future re.search should focus on the interaction network between Nrf2 and other programmed cell death pathways, develop microenvironment-re. sponsive nanomedicines, and establish cross-scale evaluation systems to promote the transition of acute lung injury treatment from mo. lecular mechanisms to precision medicine. |
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