| 任丽,张美霞,吴冬梅.溃疡性结肠炎病人血清白蛋白 /球蛋白比值、可溶性人白细胞抗原 -G水平与肠道菌群、炎症因子相关性的研究[J].安徽医药,2026,30(6):1115-1119. |
| 溃疡性结肠炎病人血清白蛋白 /球蛋白比值、可溶性人白细胞抗原 -G水平与肠道菌群、炎症因子相关性的研究 |
| Study on the correlation of serum albumin/globulin ratio and soluble human leukocyte antigen-G levels with intestinal flora and inflammatory factors in patients with ulcerative colitis |
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| DOI：10.3969/j.issn.1009-6469.2026.06.011 |
| 中文关键词: 结肠炎，溃疡性 白蛋白 /球蛋白比值 可溶性人白细胞抗原 -G 肠道菌群 相关性 |
| 英文关键词: Colitis, ulcerative Albumin/globulin ratio Soluble human leukocyte antigen-G Gut microbiota Correlation |
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| 摘要点击次数: 52 |
| 全文下载次数: 17 |
| 中文摘要: |
| 目的探讨溃疡性结肠炎( UC)病人血清白蛋白 /球蛋白比值( AGR)、可溶性人白细胞抗原 -G(sHLA-G)水平与肠道菌群、炎症因子相关性。方法前瞻性研究。选取武警四川总队医院 2022年 5月至 2024年 5月收治的 UC病人 146例作为研究组，根据病人疾病活动度分为活动期组( n=84)和缓解期组( n=62)；另选取同期在该院健康体检者 146例作为健康组。酶联免疫吸附分析( ELISA)检测 sHLA-G以及炎症因子水平［白细胞介素( IL)-4、IL-6、IL-23和肿瘤坏死因子 α(TNF-α)］计算 AGR；采用 MicroScan微生物鉴定分析系统检测肠道菌群分布， Pearson相关性分析检验血清 AGR、sHLA-G与肠道菌群、，炎症因子相关性， logistic回归分析探索 UC影响因素。结果研究组血清 AGR(1.12±0.19比 1.98±0.24)、双歧杆菌、乳酸杆菌、拟杆菌、 IL-4显著低于健康组( P<0.05)sHLA-G水平［( 2.04±0.30)mg/L比( 0.55±0.12)mg/L］、大肠杆菌、肠球菌、大肠埃希菌、 IL-6、IL-23、 TNF-α显著高于健康组( P<0.，05)。活动期组血清 AGR、双歧杆菌、乳酸杆菌、拟杆菌、 IL-4显著低于缓解期组( P<0.05)sHLA-G水平、大肠杆菌、肠球菌、大肠埃希菌、 IL-6、IL-23、TNF-α显著高于缓解期组( P<0.05)。血清 AGR与 sHLA-G呈负相，关( P<0.05)二者均与大肠杆菌、双歧杆菌、乳酸杆菌、肠球菌、大肠埃希菌、拟杆菌、 IL-4、IL-6、IL-23、TNF-α有关( P<0.05)。多因素 logistic归分析， sHLA-G、大肠杆菌、肠球菌、大肠埃希菌、 IL-6、IL-23、TNF-α为影响 UC病人的危险因素( P<0.05)，AGR、双歧回，杆菌、乳酸杆菌、拟杆菌、 IL-4为保护因素( P<0.05)。结论 UC病人血清 AGR明显降低， sHLA-G水平明显升高，二者均为 UC的影响因素，且与肠道菌群分布及炎症因子有关。 |
| 英文摘要: |
| Objective To explore the correlation between serum albumin/globulin ratio (AGR), soluble human leukocyte antigen-G (sHLA-G) levels, and gut microbiota and inflammatory factors in patients with ulcerative colitis (UC).Methods A prospective study. Atotal of 146 UC patients admitted to the Armed Police Sichuan General Hospital from May 2022 to May 2024 were selected as the studygroup and divided into the active stage group (n=84) and remission stage group (n=62) according to disease activity; meanwhile, 146healthy individuals who underwent physical examinations at the hospital during the same period were selected as the healthy group. En.zyme-linked immunosorbent assay (ELISA) was used to detect levels of sHLA-G and inflammatory factors [interleukin-4 (IL-4), IL-6, IL-23, and tumor necrosis factor-α (TNF-α)], and AGR was calculated. Gut microbiota distribution was detected using the MicroScanmicrobial identification analysis system. Pearson correlation analysis was conducted to examine the relationship between serum AGR,sHLA-G, gut microbiota, and inflammatory factors, and logistic regression analysis was performed to explore influencing factors of UC.Results The study group had significantly lower serum AGR (1.12±0.19 vs. 1.98±0.24), Bifidobacterium, Lactobacillus, Bacteroides,and IL-4 compared with the healthy group (P<0.05), while sHLA-G levels [(2.04±0.30) mg/L vs. (0.55±0.12) mg/L], Escherichia coli, En. terococcus, E. coli, IL-6, IL-23, and TNF-α were significantly higher than in the healthy group (P<0.05). In the active phase group, se. rum AGR, Bifidobacterium, Lactobacillus, Bacteroides, and IL-4 were significantly lower than in the remission phase group (P<0.05), whereas sHLA-G levels, Escherichia coli, Enterococcus, E. coli, IL-6, IL-23, and TNF-α were significantly higher than in the remission phase group (P<0.05). Serum AGR was negatively correlated with sHLA-G(P<0.05), and both were associated with Escherichia coli, Bi. fidobacterium, Lactobacillus, Enterococcus, E. coli, Bacteroides, IL-4, IL-6, IL-23, and TNF-α(P<0.05). Multivariate logistic regression analysis showed that sHLA-G, Escherichia coli, Enterococcus, E. coli, IL-6, IL-23, and TNF-α are risk factors for UC patients (P<0.05), while AGR, Bifidobacterium, Lactobacillus, Bacteroides, and IL-4 are protective factors (P<0.05).Conclusion UC patients have signifi. cantly reduced serum AGR and significantly increased sHLA-G levels; both are influencing factors of UC and are related to gut microbi. ota distribution and inflammatory factors. |
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