| 邓丽霞,赵青莲,高晓培,等.宫颈癌病人血清微 RNA-190、微 RNA-141-3p表达与放疗敏感性及预后的关系[J].安徽医药,2026,30(6):1126-1130. |
| 宫颈癌病人血清微 RNA-190、微 RNA-141-3p表达与放疗敏感性及预后的关系 |
| The relationship between serum miR-190, miR-141-3p expression and radiotherapy sensitivity and prognosis in cervical cancer patients |
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| DOI：10.3969/j.issn.1009-6469.2026.06.013 |
| 中文关键词: 宫颈肿瘤 微 RNA-190 微 RNA-141-3p 放疗敏感性 预后 |
| 英文关键词: Uterine cervical neoplasms MiR-190 MiR-141-3p Radiotherapy sensitivity Prognosis |
| 基金项目:河北省医学科学研究课题计划( 20241081) |
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| 中文摘要: |
| 目的对宫颈癌病人血清微 RNA(miR)-190、miR-141-3p表达与放疗敏感性及预后的关系进行探讨分析。方法前瞻性选取 2019年 10月至 2021年 10月保定市第一中心医院收治的 165例国际妇产科联盟( FIGO)分期处于 ⅡB~ⅣA期的宫颈癌病人及 165例妇科体检健康的志愿者为研究对象，分别纳入宫颈癌组和健康组。根据宫颈癌病人对放疗的敏感性，分为放疗敏感组 105例、放疗抵抗组 60例；根据预后死亡情况，分为死亡组 53例、生存组 112例。采用实时荧光定量逆转录聚合酶链反应( qRT-PCR)检测血清 miR-190、miR-141-3p水平；采用 Kaplan-Meier生存曲线分析 miR-190、miR-141-3p水平与宫颈癌病人预后的关系；采用多因素 Cox分析探索宫颈癌病人的预后影响因素。结果宫颈癌组病人血清 miR-190水平显著低于健康组， miR-141-3p水平显著高于健康组(P<0.05)。放疗抵抗组病人血清 miR-190水平显著低于放疗敏感组(0.63±0.18比 0.77±0.21)， miR-141-3p水平显著高于放疗敏感组( 1.35±0.26比 1.19±0.23)(P<0.05)。 miR-190、miR-141-3p水平与肿瘤长径、淋巴结转移及放疗效果有关( P<0.05)。死亡组病人血清 miR-190水平显著低于生存组( 0.56±0.14比 0.80±0.19)miR-141-3p水平显著高于生存组( 1.41±0.26比 1.17±0.24)(P<0.05)。血清 miR-190、miR-141-3p高表达病人 3年生存率分别为，85.00%(68/80)、 49.43%(43/87)，miR-190、miR-141-3p低表达病人 3年生存率分别为 51.76%(44/85)、 88.46%(69/78)，miR-190低表达、 miR-141-3p高表达病人 3年生存率显著低于 miR-190高表达、 miR-141-3p低表达( P<0.05)。肿瘤长径 ≥4 cm、淋巴结转移、放疗抵抗及高水平 miR-141-3p为病人预后死亡的危险因素，高水平 miR-190为保护因素( P<0.05)。结论宫颈癌病人血清 miR-190表达降低， miR-141-3p表达升高，二者水平与放疗敏感性及预后密切相关。 |
| 英文摘要: |
| Objective To investigate the relationship between serum microRNA (miR)-190 and miR-141-3p expression and radio. therapy sensitivity and prognosis in cervical cancer patients.Methods From October 2019 to October 2021, 165 cervical cancer pa.tients at FIGO stages ⅡB to ⅣA admitted to Baoding NO.1 Central Hospital and 165 healthy volunteers with normal gynecological ex.amination results were prospectively selected as study subjects and assigned to the cervical cancer group and the healthy group, respec.tively. Based on sensitivity to radiotherapy, cervical cancer patients were divided into a radiotherapy sensitive group (105 cases) and aradiotherapy resistant group (60 cases); based on mortality outcomes, they were divided into a mortality group (53 cases) and a survivalgroup (112 cases). Real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to detect serum levels of miR-190 and miR-141-3p. Kaplan-Meier survival curves were employed to analyze the relationship between miR-190 and miR-141-3plevels and patient prognosis. Multifactorial Cox regression analysis was used to identify prognostic factors in cervical cancer patients.Results Serum miR-190 levels in the cervical cancer group were significantly lower than those in the healthy group, while miR-141-3p levels were significantly higher (P<0.05). Serum miR-190 levels in the radiotherapy resistant group were significantly lower than those in the radiotherapy sensitive group (0.63±0.18 vs. 0.77±0.21), while miR-141-3p levels were significantly higher in the radiotherapy re. sistant group than in the radiotherapy sensitive group (1.35±0.26 vs. 1.19±0.23) (P<0.05). miR-190 and miR-141-3p levels were associ. ated with tumor longest diameter, lymph node metastasis, and radiotherapy response (P<0.05). Serum miR-190 levels in the mortality group were significantly lower than those in the survival group (0.56±0.14 vs. 0.80±0.19), while miR-141-3p levels were significantly higher in the survival group (1.41±0.26 vs. 1.17±0.24) (P<0.05). The 3-year survival rates for patients with high serum miR-190 and miR-141-3p expression were 85.00% (68/80) and 49.43% (43/87), respectively, while those with low expression were 51.76% (44/85)and 88.46% (69/78), respectively. The 3-year survival rates for patients with low miR-190 expression and high miR-141-3p expression were significantly lower than those for patients with high miR-190 expression and low miR-141-3p expression (P<0.05). Tumor longest diameter ≥4 cm, lymph node metastasis, radiotherapy resistance and high levels of miR-141-3p were risk factors for patient mortality, while high levels of miR-190 were a protective factor (P<0.05).Conclusion Serum miR-190 expression decreases and miR-141-3p ex.pression increases in patients with cervical cancer, and both levels are closely associated with sensitivity to radiation therapy and prog.nosis. |
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