文章摘要
张晟,周辉.三碘甲状腺原氨酸在脑外伤预后模型中的研究价值[J].安徽医药,待发表.
三碘甲状腺原氨酸在脑外伤预后模型中的研究价值
投稿时间:2021-11-29  录用日期:2021-12-22
DOI:
中文关键词: 脑外伤  预后模型  三碘甲状腺原氨酸
英文关键词: 
基金项目:江苏省第十四批“六大高峰”高层次人才选拔培养资助方案(WSW-166)
作者单位邮编
张晟 徐州医科大学附属连云港医院 222000
周辉 连云港市第一人民医院(徐州南京锦州医科大学附属连云港医院) 
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中文摘要:
      【目的】探究三碘甲状腺原氨酸纳入脑外伤预后模型中的可行性。【方法】回顾性分析连云港市第一人民医院收治神经外科外伤组患者临床资料,建立预后模型,检测模型性能。【结果】逐步回归及多因素分析后,年龄,GCS评分,瞳孔对光反射双侧阴性,HCT评分,抗凝、抗血小板药物服用史,白细胞计数及T3水平均与预后不良相关。模型A包括年龄,GCS评分,瞳孔对光反射;模型B在模型A的基础上添加HCT评分及抗凝、抗血小板药物服用史;模型C在模型B的基础上添加白细胞计数及T3水平。随着纳入因素的增多,模型的性能逐渐增强。模型C是最佳预测模型,经内部验证及外部验证依然有较强性能。【结论】T3水平与预后不良成负相关,做为实验室指标与白细胞计数共同纳入预后模型可以提高模型的性能。
英文摘要:
      Objective:To explore the feasibility of taking triiodothyronine into the prognostic model of brain injury. Methods: The clinical data of patients with neurosurgical trauma treated in the first people's Hospital of Lianyungang were analyzed retrospectively, the prognostic model was established, and the performance of the model was tested. Results: After stepwise regression and multivariate analysis, age, Glasgow coma scale (GCS) score, negative bilateral pupil reflex, Helsinki CT (HCT) score, history of anticoagulant and antiplatelet medication, white blood cell count and T3 level were all associated with poor prognosis. Model A included age, GCS score, pupil reflex to light, model B added HCT score and anticoagulant and antiplatelet medication history on the basis of model A, and model C added white blood cell count and T3 level on the basis of model B. With the increase of included factors, the performance of the model is gradually enhanced. Model C is the best prediction model, which has strong performance after internal verification set external verification. Conclusion: T3 level is negatively correlated with poor prognosis, and its inclusion with white blood cell count in the prognostic model can improve the performance of the model.
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