| 林红莲.MRI评分及血清GPX1、TAZ与前置胎盘患者胎盘植入程度关系及对妊娠结局预测价值[J].安徽医药,待发表. |
| MRI评分及血清GPX1、TAZ与前置胎盘患者胎盘植入程度关系及对妊娠结局预测价值 |
|
| 投稿时间：2024-09-02 录用日期：2024-10-23 |
| DOI： |
| 中文关键词: 前置胎盘 胎盘植入 MRI评分 GPX1 TAZ 妊娠结局 |
| 英文关键词: |
| 基金项目:新疆维吾尔自治区自然科学基金 资助项目：2019D12C125 |
|
| 摘要点击次数: 192 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的 探讨磁共振成像（MRI）评分及血清谷胱甘肽过氧化物酶（GPX1）、转录共激活因子PDZ结合基序（TAZ）与前置胎盘患者胎盘植入程度关系及对妊娠结局预测价值。方法 选取2020年1月～2023年12月新疆巴州人民医院收治的152例前置胎盘患者作为研究组，另按照1:1比例纳入同期152例健康体检孕妇作为对照组。比较两组入院时MRI评分及血清GPX1、TAZ mRNA表达，Spearman分析MRI评分及血清GPX1、TAZ mRNA与胎盘植入程度相关性，后根据研究组妊娠结局分为不良亚组和良好亚组，采用单、多因素分析前置胎盘患者不良妊娠结局影响因素，绘制受试者工作特征曲线（ROC）及曲线下面积（AUC）分析MRI评分及血清GPX1、TAZ mRNA预测前置胎盘患者不良妊娠结局价值。结果 （1）研究组植入型/穿透型MRI评分＞黏连型＞阴性，GPX1、TAZ mRNA表达＜黏连型＜阴性＜对照组（P＜0.05）。（2）胎盘植入患者MRI评分与胎盘植入程度成正比，血清GPX1、TAZ mRNA表达与植入程度成反比（P＜0.05）。（3）研究组所有患者均随访至妊娠结束1个月，不良妊娠结局发生率为34.87%。不良亚组胎盘植入程度-植入型/穿透型所占比例、剖宫产史、MRI评分高于良好亚组，血清GPX1、TAZ mRNA表达低于良好亚组（P＜0.05）。（4）胎盘植入程度（OR=1.466）、剖宫产史（OR=1.938）、MRI评分（OR=1.645）、GPX1（OR=0.690）、TAZ mRNA（OR=0.696）是前置胎盘患者不良妊娠结局影响因素（P＜0.05）。（5）MRI评分及血清GPX1、TAZ mRNA联合预测前置胎盘患者不良妊娠结局价值优于单一预测价值（AUC：0.924 vs 0.810、0.784、0.824）。结论 置胎盘患者胎盘植入程度与MRI评分及血清GPX1、TAZ mRNA表达显著相关，联合检测可显著提高妊娠结局预测价值，指导临床诊治，改善妊娠结局。 |
| 英文摘要: |
| Objective To investigate the relationship between magnetic resonance imaging (MRI) scores, serum glutathione peroxidase (GPX1), transcriptional coactivator PDZ-binding motif (TAZ) and placental implantation degree in patients with placenta previa and the predictive value of pregnancy outcomes. Methods A total of 152 patients with placenta previa admitted to Bazhou People`s Hospital in Xinjiang from January 2020 to December 2023 were selected as the study group, and 152 healthy pregnant women in the same period were included as the control group according to 1:1 ratio. MRI scores and serum GPX1 and TAZ mRNA expressions were compared between the two groups at admission, and the correlation between MRI scores and serum GPX1 and TAZ mRNA and placental implantation degree was analyzed by Spearman. The study group was then divided into poor subgroup and good subgroup according to pregnancy outcomes, single and multiple factors were used to analyze the influencing factors of adverse pregnancy outcomes in placenta previa patients, and receiver operating characteristic curve (ROC) and area under the curve (AUC) were plotted to analyze the value of MRI score and serum GPX1 and TAZ mRNA in predicting adverse pregnancy outcomes in placenta previa patients. Results (1) The implantable/penetrating MRI scores of the study group were > adhesion > negative, and the mRNA expressions of GPX1 and TAZ were < adhesion < negative < control group (P < 0.05). (2) MRI scores of patients with placenta implantation were proportional to the degree of placenta implantation, and serum GPX1 and TAZ mRNA expressions were inversely proportional to the degree of placenta implantation (P < 0.05). (3) All patients in the study group were followed up to 1 month after the end of pregnancy, and the incidence of adverse pregnancy outcomes was 34.87%. The degree of placenta accretion, the proportion of implant type/penetration type, cesarean section history and MRI score in the poor subgroup were higher than those in the good subgroup, and the mRNA expressions of GPX1 and TAZ in serum were lower than those in the good subgroup (P < 0.05). (4) The degree of placenta implantation (OR=1.466), history of cesarean section (OR=1.938), MRI score (OR=1.645), GPX1 (OR=0.690) and TAZ mRNA (OR=0.696) were the influencing factors of adverse pregnancy outcomes in patients with placenta previa (P < 0.05). (5) The combined value of MRI score and serum GPX1 and TAZ mRNA in predicting adverse pregnancy outcomes in placenta previa patients was better than that of single prediction value (AUC: 0.924 vs 0.810, 0.784, 0.824). Conclusion The degree of placenta implantation in patients with placenta implantation is significantly correlated with MRI score and serum GPX1 and TAZ mRNA expression. Combined detection can significantly improve the predictive value of pregnancy outcome, guide clinical diagnosis and treatment, and improve pregnancy outcome. |
|
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
